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Kun-Han Lue, Ph.D.

Name

Kun-Han Lue

Title

Associate professor

Education

PhD, Department of Biomedical Engineering and Environment sciences, National Tsing Hua University

Research interest

Nuclear Medicine Image Processing and Analysis, Nuclear Medicine Physics and Instrumentation, Clinical Nuclear Medicine Technology

E-mail

khlue@gms.tcu.edu.tw

TEL

(03)8565301 ext:12228

 
Journal Papers (*Corresponding author):
01. Yu-Hung Chen, Li Min Yong, Yi-Feng Wu, Shu-Hsin Liu, Kun-Han Lue*. Influence of Feature Aggregation and Selection Methods on 18F-FDG PET Radiomics for Survival Prediction in Patients with Lymphoma. Nucl Med Commun. 2026;47:462-469 (SCIE).
02. Kun-Han Lue, Yu-Hung Chen, Sung-Chao Chu, Chih-Bin Lin, Bee-Song Chang, Pau-Yuan Chang, Shu-Hsin Liu. Combining the prognostic values of entropy-based heterogeneity features from 18F-fluorodeoxyglucose PET and transmission computed tomography using machine learning in patients with lung adenocarcinoma undergoing curative surgery. Nucl Med Commun. 2026;47:479-489 (SCIE).
03. Kun-Han Lue, Yung-Hsuan Wang, Yu-Hung Chen, Sung-Chao Chu, Chih-Bin Lin, Shu-Hsin Liu. The prognostic value of 18F-FDG PET-derived whole-body feature in patients with lung adenocarcinoma treated with EGFR-targeted therapy. Ann Nucl Med. 2026;40:121-135 (SCIE).
04. Kun-Han Lue, Yu-Hung Chen, Sung-Chao Chu, Chih-Bin Lin, Tso-Fu Wang, Shu-Hsin Liu. Prognostic value of combining clinical factors, 18F-FDG PET-based intensity, volumetric features, and deep learning predictor in patients with EGFR-mutated lung adenocarcinoma undergoing targeted therapies: a cross-scanner and temporal validation study. Ann Nucl Med. 2024;38:647-658 (SCIE).
05. Yu-Hunga Chen, Kun-Han Lue, Sung-Chao Chu, Chih-Bine Lin, Shu-Hsin Liu. The value of 18F-fluorodeoxyglucose positron emission tomography-based radiomics in non-small cell lung cancer. Tzu Chi Med J. 2024 Sep 3;37(1):17-27 (ESCI).
06. Yu-Hung Chen, Kuo-Yi Kan, Shu-Hsin Liu, Hsin-Hon Lin, Kun-Han Lue*. Impact of respiratory motion on 18F-FDG PET radiomics stability: Clinical evaluation with a digital PET scanner. J Appl Clin Med Phys. 2023;24:e14200 (SCIE).
07. Kun-Han Lue, Yu-Hung Chen, Sung-Chao Chu, Bee-Song Chang, Chih-Bin Lin, Yen-Chang Chen, Hsin-Hon Lin, Shu-Hsin Liu. A comparison of 18F-FDG PET-based radiomics and deep learning in predicting regional lymph node metastasis in patients with resectable lung adenocarcinoma: a cross-scanner and temporal validation study. Nucl Med Commun. 2023;44:1094-1105 (SCIE).
08. Kun-Han Lue*, Yu-Hung Chen, Yi-Feng Wu, Shu-Hsin Liu. Influence of the methodological aspects of the dichotomization of total metabolic tumor volume measured through baseline fluorine-18 fluorodeoxyglucose PET on survival prediction in lymphoma. Nucl Med Commun. 2023;44:74–80 (SCIE).
09. Bee-Song Chang, Tai-Chu Peng, Kun-Han Lue, Yi-Feng Wu, Chun-Hou Huang. Comprehensive assessment of the clinical risk factors of postoperative adverse events and survival in patients with non-small-cell lung cancer. In Vivo. 2023;37:1358-1364 (SCIE).
10. Yu-Hung Chen, Kun-Han Lue, Chih-Bin Lin, Kuang-Chi Chen, Sheng-Chieh Chan, Sung-Chao Chu, Bee-Song Chang, Yen-Chang Chen. Genomic and glycolytic entropy are reliable radiogenomic heterogeneity biomarkers for non-small cell lung cancer. Int J Mol Sci. 2023;24:3988 (SCIE).
11. Min-Feng Shih, Kun-Han Lue, Tso-Fu Wang, Sung-Chao Chu, Chun-Hou Huang. Association between the neutrophil-to-lymphocyte ratio and infection and survival in diffuse large B cell lymphoma. In Vivo. 2023;37:948-954 (SCIE).
12. Yu-Hung Chen, Kun-Han Lue, Sung-Chao Chu, Bee-Song Chang, Chih-Bin Lin. The combined tumor-nodal glycolytic entropy improves survival stratification in nonsmall cell lung cancer with locoregional disease. Nucl Med Commun. 2023;44:100–107 (SCIE).
13. Yu-Hung Chen, Yen-Chang Chen, Kun-Han Lue*, Sung-Chao Chu*, Bee-Song Chang, Ling-Yi Wang, Ming-Hsun Li, Chih-Bin Lin. Glucose metabolic heterogeneity correlates with pathological features and improves survival stratification of resectable lung adenocarcinoma. Ann Nucl Med. 2023;37:139-150 (SCIE).
14. Kun-Han Lue, Chun-Hou Huang, Tsung-Cheng Hsieh, Shu-Hsin Liu, Yi-Feng Wu, Yu-Hung Chen. Systemic inflammation index and tumor glycolytic heterogeneity help risk stratify patients with advanced EGFR-mutated lung adenocarcinoma treated with tyrosine kinase inhibitor therapy. Cancers. 2022;14:309 (SCIE).
15. Kun-Han Lue, Sung-Chao Chu, Ling-Yi Wang, Yen-Chang Chen, Ming-Hsun Li, Bee-Song Chang, Sheng-Chieh Chan, Yu-Hung Chen, Chih-Bin Lin, Shu-Hsin Liu. Tumor glycolytic heterogeneity improves detection of regional nodal metastasis in patients with lung adenocarcinoma. Ann Nucl Med. 2022;36:256-266 (SCIE).
16. Chun-Hou Huang, Kun-Han Lue, Peir-Rorg Chen, Tsung-Cheng Hsieh, Yu-Fu Chou. Association between sarcopenia and immediate complications and mortality in patients with oral cavity squamous cell carcinoma undergoing surgery. Cancers. 2022;14:785 (SCIE).
17. Chun-Hou Huang, Peir-Rorg Chen, Kun-Han Lue, Tsung-Cheng Hsieh, Yu-Fu Chou. Evaluation of sarcopenia, frailty, and inflammation on adverse events and survival outcomes in patients with oral cavity squamous cell carcinoma under adjuvant chemoradiotherapy. J Pers Med. 2021;11:936 (SCIE).
18. Yu-Hung Chen, Sung-Chao Chu, Ling-Yi Wang, Tso-Fu Wang, Kun-Han Lue, Chih-Bin Lin, Bee-Song Chang, Dai-Wei Liu, Shu-Hsin Liu, Sheng-Chieh Chan. Prognostic value of combining primary tumor and nodal glycolytic–volumetric parameters of 18F-FDG PET in patients with non-small cell lung cancer and regional lymph node metastasis. Diagnostics. 2021;11:1065 (SCIE).
19. Kun-Han Lue, Yi-Feng Wu, Hsin-Hon Lin, Tsung-Cheng Hsieh, Shu-Hsin Liu, Sheng-Chieh Chan, Yu-Hung Chen. Prognostic value of baseline radiomic features of 18F-FDG PET in patients with diffuse large B-cell lymphoma. Diagnostics. 2021;11:36 (SCIE).
20. Yu-Hung Chen, Tso-Fu Wang, Sung-Chao Chu, Chih-Bin Lin, Ling-Yi Wang, Kun-Han Lue, Shu-Hsin Liu, Sheng-Chieh Chan. Incorporating radiomic features of pretreatment 18F-FDG PET improves survival stratification in patients with EGFR-mutated lung adenocarcinoma. PLoS ONE. 2020;15:e0244502 (SCIE).
21. Yu-Hung Chen, Hwa-Tsung Chen, Ming-Che Lee, Shu-Hsin Liu, Ling-Yi Wang, Kun-Han Lue, Sheng-Chieh Chan. Preoperative 18F-fluorocholine PET/CT for detection of hyperfunctioning parathyroid glands in secondary or tertiary hyperparathyroidism. Ann Nucl Med. 2020;34:527-537 (SCIE).
22. Kun-Han Lue, Yi-Feng Wu, Shu-Hsin Liu, Tsung-Cheng Hsieh, Keh-Shih Chuang, Hsin-Hon Lin, Yu-Hung Chen. Intratumour heterogeneity assessed by 18F-FDG PET predicts treatment response and survival outcomes in Hodgkin lymphoma. Acad Radiol. 2020;27:e183-e192 (SCIE).
23. Chun-Hou Huang, Kun-Han Lue, Tsung-Cheng Hsieh, Shu-Hsin Liu, Tso-Fu Wang, Tai-Chu Peng. Association between sarcopenia and clinical outcomes in patients with esophageal cancer under neoadjuvant therapy. Anticancer Res. 2020;40:1175-1181 (SCIE).
24. Kun-Han Lue, Yi-Feng Wu, Shu-Hsin Liu, Tsung-Cheng Hsieh, Keh-Shih Chuang, Hsin-Hon Lin, Yu-Hung Chen. Prognostic value of pretreatment radiomic features of 18F-FDG PET in Hodgkin lymphoma. Clin Nucl Med. 2019;44:e559-e565 (SCIE).
25. Yu-Hung Chen, Kun-Han Lue, Sung-Chao Chu, Bee-Song Chang, Ling-Yi Wang, Dai-Wei Liu, Shu-Hsin Liu, Yin-Kai Chao, Sheng-Chieh Chan. Combining radiomic features and traditional 18F-FDG PET parameters with clinical profiles to improve prognostic stratification in esophageal squamous cell carcinoma. Ann Nucl Med. 2019;33:657-670 (SCIE).
26. Yu-Hung Chen, Ching-Jung Chen, Ling-Yi Wang, Kun-Han Lue, Ching-Lin Sung, Shu-Hsin Liu. Comparison of attenuation correction methods for semiquantitative parameters of TRODAT-1 SPECT. Ann Nucl Med Mol Imaging. 2019;32:63-67.
27. Hung-Jen Hsieh, Kun-Han Lue, Hsin-Chi Tsai, Chau-Chin Lee, Shin-Yuan Chen, Pan-Fu Kao. 18F-FDOPA PET demonstrates dopaminergic system abnormalities in obsessive–compulsive disorder. Psychiatry Clin Neurosci. 2014;68:292-298 (SCIE).
28. Kun-Han Lue, Hsin-Hon Lin, Chih-Hao K. Kao, Hung-Jen Hsieh, Shu-Hsin Liu, Keh-Shih Chuang. A simple algorithm for subregional striatal uptake analysis with partial volume correction in dopaminergic PET imaging. Ann Nucl Med. 2014;28:33-41 (SCIE).
29. I-Cheng Chang, Kun-Han Lue, Hung-Jen Hsieh, Shu-Hsin Liu, Chih-Hao K. Kao. Automated striatal uptake analysis of 18F-FDOPA PET images in Parkinson disease. Ann Nucl Med. 2011;25:796-803 (SCIE).
30. Hung-Jen Hsieh, Kun-Han Lue, Chih-Hao K. Kao, Yung-Hsiang Hsu, Ming-Chien Liu, Pan-Fu Kao. Portosystemic collateral circulation demonstrated by Tc-99m-RBC SPECT/CT. Clin Nucl Med. 2009;34:958-959 (SCIE).
31. Hung-Jen Hsieh, Kun-Han Lue, Bee-Song Chang, Chih-Hao K. Kao, Shu-Hsin Liu, Pan-Fu Kao. Port-A catheter fracture identified on PET/CT. Ann Nucl Med Sci. 2009;22:47-51.
32. Hung-Jen Hsieh, Kun-Han Lue. Cephalad malposition of kidney as thoracic abnormality in Tc-99m MDP bone scintigraphy. Tzu Chi Med J. 2008;20:314-317 (ESCI).
 
Conference Papers:
01. Kun-Han Lue, Tien-Hsin Chang, Ching-Yuan Chen, Yu-Hung Chen, Hsin-Hon Lin. Coronary artery disease prediction by machine learning radiomics with SPECT MPI polar maps. Japan Society of Nuclear Medicine, 2025 Annual Scientific Meeting, Kyoto, Japan.
02. Yu-Hung Chen, Kun-Han Lue, Sheng-Chuan Huang, Yi-Feng Wu, Sung-Chao Chu, Shu-Hsin Liu. Value of whole-body 18F-FDG PET radiomics for predicting bone marrow involvement in patients with diffuse large B-cell lymphoma. Taiwan Society of Nuclear Medicine, 2025 Annual Meeting, Taipei, Taiwan.
03. Tan Sze Ian, Yu-Hung Chen, Kun-Han Lue, Shu-Hsin Liu. Assessing respiratory motion stability of novel 18F-FDG PET-derived morphological features. Taiwan Society of Nuclear Medicine, 2025 Annual Meeting, Taipei, Taiwan.
04. Kun-Han Lue, Yu-Hung Chen. AI Task Force radiomic challenge results and presentations: Best performing model for continuous outcomes. Society of Nuclear Medicine and Molecular Imaging (SNMMI), 2024 Annual Meeting, Toronto, Canada.
05. Yu-Hung Chen, Kun-Han Lue, Kuang-Chi Chen, Shu-Hsin Liu. Comparing machine-learning models with 18F-FDG PET-based radiomics in subtyping EGFR mutations of lung adenocarcinoma. Taiwan Society of Nuclear Medicine, 2024 Annual Meeting, Taipei, Taiwan.
06. Yu-Hung Chen, Kun-Han Lue, Kuang-Chi Chen, Shu-Hsin Liu. A machine-learning approach using 18F-FDG PET-based radiomics to predict regional lymph node metastasis in patients with resectable lung adenocarcinoma. Taiwan Society of Nuclear Medicine, 2024 Annual Meeting, Taipei, Taiwan.
07. Tan Sza Lan, Kun-Han Lue, Yu-Hung Chen, Shu-Hsin Liu. The effect of resampling on 18F-FDG PET-based radiomic features. Taiwan Society of Nuclear Medicine, 2024 Annual Meeting, Taipei, Taiwan.
08. Yu-Qun Chu, Ting-Chen Huang, Yu-Hung Chen, Kun-Han Lue, Yen-Chang Chen, Shu-Hsin Liu. Correlation of 18F-FDG PET, structural CT, and histopathological heterogeneity features and their prognostic values in lung adenocarcinoma. Taiwan Society of Nuclear Medicine, 2024 Annual Meeting, Taipei, Taiwan.
09. Ting-Chen Huang, Yu-Qun Chu, Yu-Hung Chen, Kun-Han Lue, Shu-Hsin Liu. Intestinal uptake of 99mTc-diphosphonate and 18F-fluoride bone-seeking tracers: A report of three cases. Taiwan Society of Nuclear Medicine, 2024 Annual Meeting, Taipei, Taiwan.
10. Kun-Han Lue, Kuo-Yi Kan, Yu-Hung Chen, Shu-Hsin Liu, I-Ling Shih, Hsin-Hon Lin. Clinical evaluation of 18F-FDG PET radiomics stability to respiratory motion using a data-driven respiratory gating algorithm. European Association of Nuclear Medicine (EANM), 2023 Annual Congress, Vienna, Austria.
11. Kun-Han Lue, Yu-Hung Chen, Li Min Yong, Xin Yi Wong, Shu-Hsin Liu, Hsin-Hon Lin. Convolutional neural network for prediction of early disease progression in patients with advanced EGFR-mutated lung adenocarcinoma receiving tyrosine kinase inhibitor therapy based on 18F-FDG PET images. EANM, 2023 Annual Congress, Vienna, Austria.
12. Li Min Yong, Xin Yi Wong, Yu-Hung Chen, Shu-Hsin Liu, Hsin-Hon Lin, Kun-Han Lue. Effect of feature selection methods on prognostic analysis of 18F-FDG PET radiomics in lymphoma. EANM, 2023 Annual Congress, Vienna, Austria.
13. Xin Yi Wong, Li Min Yong, Yu-Hung Chen, Shu-Hsin Liu, Kun-Han Lue. Using different dichotomization methods for lesion dissemination to predict survival outcomes in lymphoma patients. EANM, 2023 Annual Congress, Vienna, Austria.
14. Yu-Hung Chen, Kun-Han Lue, Sung-Chao Chu, Kuang-Chi Chen, Shu-Hsin Liu. Deep learning model for categorizing tumor mutation burden in non-small cell lung cancer. Taiwan Society of Nuclear Medicine, 2023 Annual Meeting, Taichung, Taiwan.
15. Ho-Yan Rong, Yu-Hung Chen, Kun-Han Lue, Shu-Hsin Liu. Cross-scanner validation of the prognostic value of glycolytic entropy in lung cancer. Taiwan Society of Nuclear Medicine, 2023 Annual Meeting, Taichung, Taiwan.
16. Ho Tim Shek, Kun-Han Lue, Chao-Yueh Yu, Chih-Chieh Chiang, Tzu-Pei Su, Hsin-Hon Lin. Deep learning-based automatic segmentation for myocardial perfusion SPECT imaging using V-Net. International Symposium of Medical Imaging and Radiological Sciences, 2023, Kaohsiung, Taiwan.
17. Yu-Hung Chen, Kun-Han Lue. Evaluation of radiomic feature reliability in lower resolution images using reduced-matrix-size 18F-FDG PET. Taiwan Society of Nuclear Medicine, 2022 Annual Meeting, Taipei, Taiwan.
18. Yu-Hung Chen, Kuang-Chi Chen, Kun-Han Lue, Sung-Chao Chu. Correlation of 18F-FDG PET features with glucose metabolic signature gene mutations in non-small cell lung cancer. Taiwan Society of Nuclear Medicine, 2022 Annual Meeting, Taipei, Taiwan.
19. Chung-Ying Huang, Yu-Hung Chen, Kun-Han Lue, Yi-Feng Wu, Sung-Chao Chu. Prognostic models combining systemic inflammation markers and tumor glycolytic-volumetric product in NSCLC with regional lymph node metastasis. Taiwan Society of Nuclear Medicine, 2022 Annual Meeting, Taipei, Taiwan.
20. Chao-Yueh Yu, Kun-Han Lue, Ho-Ting Yang, Tzu-Pei Su, Hsin-Hon Lin. Attenuation correction for myocardial perfusion SPECT using a multi-stream 3D residual network. IEEE Nuclear Science Symposium and Medical Imaging Conference, 2021, Yokohama, Japan.
21. Yu-Hung Chen, Yen-Chang Chen, Ming-Hsun Li, Sung-Chao Chu, Kun-Han Lue. Correlation between 18F-FDG PET glycolytic features and pathological morphology in lung adenocarcinoma. Taiwan Society of Nuclear Medicine, 2021 Annual Meeting, Taichung, Taiwan.
22. Yu-Hung Chen, Sung-Chao Chu, Kun-Han Lue, Sheng-Chieh Chan, Shu-Hsin Liu. Prognostic value of 18F-FDG PET in advanced small cell lung cancer. Taiwan Society of Nuclear Medicine, 2021 Annual Meeting, Taichung, Taiwan.
23. Ching-Lin Sung, Sze Ian Tan, Shu-Hsin Liu, Sheng-Chieh Chan, Kun-Han Lue. Image quality evaluation of digital PET/CT using different scanning times and reconstruction methods. Taiwan Society of Nuclear Medicine, 2021 Annual Meeting, Taichung, Taiwan.
24. Yu-Hung Chen, Ming-Hsun Li, Sung-Chao Chu, Kun-Han Lue, Shu-Hsin Liu, Sheng-Chieh Chan. Tumor glycolytic heterogeneity from 18F-FDG PET and its association with PD-L1 expression in esophageal squamous cell carcinoma. Taiwan Society of Nuclear Medicine, 2020 Annual Meeting, Taipei, Taiwan.
25. Yu-Hung Chen, Kun-Han Lue, Shu-Hsin Liu, Sheng-Chieh Chan. Comparison of 18F-FDG PET radiomic features between different software platforms. Taiwan Society of Nuclear Medicine, 2020 Annual Meeting, Taipei, Taiwan.
26. Ching-Lin Sung, Yu-Hung Chen, Kun-Han Lue, Shu-Hsin Liu, Sung-Chao Chu, Ching-Chun Ho. Identifying predictors of Tc-99m bone radiopharmaceutical interference in DXA using LASSO and logistic regression. Taiwan Society of Nuclear Medicine, 2020 Annual Meeting, Taipei, Taiwan.
27. Kun-Han Lue, Yu-Hung Chen, Hsin-Hon Lin, Yi-Feng Wu, Shu-Hsin Liu, Sheng-Chieh Chan. Metabolic tumor volume dichotomization methods for survival prediction in Hodgkin lymphoma. Australian and New Zealand Society of Nuclear Medicine, 2020 Annual Meeting, Sydney, Australia.
28. Kun-Han Lue, Hsin-Hon Lin, Yu-Hung Chen, Shu-Hsin Liu, Keh-Shih Chuang. Relationship between PSA kinetics and radiomic features of 18F-fluorocholine PET in prostate cancer. SNMMI, 2019 Annual Meeting, Anaheim, USA.
29. Kun-Han Lue, Hsin-Hon Lin, Yu-Hung Chen, Shu-Hsin Liu, Keh-Shih Chuang. Embedding partial volume correction in atlas-based substriatal uptake analysis for dopaminergic PET imaging. SNMMI, 2019 Annual Meeting, Anaheim, USA.
30. Hsin-Hon Lin, Chih-Chieh Chiang, Kun-Han Lue, Yu-Ching Ni, Keh-Shih Chuang. Distortion correction in dual-head PET breast imaging using an add-on Compton camera. EANM, 2016 Annual Congress, Barcelona, Spain.
31. Kun-Han Lue, Hsin-Hon Lin, Chang-Shiun Lin, Chih-Chieh Chiang, Keh-Shih Chuang. Effects of random, scatter, attenuation, and partial volume corrections on dopaminergic PET quantification. EANM, 2016 Annual Congress, Barcelona, Spain.
32. Keh-Shih Chuang, Kun-Han Lue, Hsin-Hon Lin, Hsin-Chao Wang, Yu-Ching Ni, Meei-Ling Jan. Improved attenuation correction for SPECT using iterative filtered backprojection reconstruction. EANM, 2014 Annual Congress, Gothenburg, Sweden.
33. Keh-Shih Chuang, Chih-Hung Chien, Hsin-Hon Lin, Kun-Han Lue, Chih-Chieh Chiang, Meei-Ling Jan. Dual-isotope simultaneous acquisition of Tc-99m and F-18 using PET with a beam stopper device. EANM, 2014 Annual Congress, Gothenburg, Sweden.
34. Hsin-Chau Wang, Kun-Han Lue, Hsin-Hon Lin, Keh-Shih Chuang. Improvement of attenuation correction for SPECT. International Symposium of Medical Imaging and Radiological Sciences, 2014, Taichung, Taiwan.
35. Shih-Chi Lin, Yi-Fang Wang, Kun-Han Lue, Hsin-Hon Lin, Keh-Shih Chuang. Improved scatter correction technique in PET imaging. AAPM, 2014 Annual Meeting, Austin, USA.
36. Yi-Fang Wang, Shih-Chi Lin, Chia-Hung Lu, Kun-Han Lue, Lu-Han Lai, Keh-Shih Chuang. Application of SIFT technique to microcalcification detection. AAPM, 2014 Annual Meeting, Austin, USA.
37. Kun-Han Lue, Hsin-Hon Lin, Chih-Hao K. Kao, Hung-Jen Hsieh, Shu-Hsin Liu, Keh-Shih Chuang. Partial volume correction for subregional striatal analysis in dopaminergic PET imaging. EANM, 2013 Annual Congress, Lyon, France.
38. Hsin-Hon Lin, Keh-Shih Chuang, Chih-Hung Chien, Kun-Han Lue, Chih-Chieh Chiang, Meei-Ling Jan. Simultaneous SPECT and PET dual-tracer imaging using a beam stopper device. EANM, 2013 Annual Congress, Lyon, France.
39. Kun-Han Lue, I-Cheng Chang, Hung-Jen Hsieh, Shu-Hsin Liu, Chih-Hao K. Kao. Objective manual striatal uptake analysis for 18F-FDOPA PET in Parkinson disease. Taiwan International Symposium on Radiopharmaceutical Development and Application, 2010, Hualien, Taiwan.
40. Hung-Jen Hsieh, Shin-Chi Tsai, Shin-Yuan Chen, Kun-Han Lue, Chih-Hao K. Kao. Neuronal circuitry and neuromodulatory mechanisms of deep brain stimulation in obsessive–compulsive disorder explored by 18F-FDG PET. Society of Nuclear Medicine, 2010 Annual Meeting, Utah, USA.